6/23/2023 0 Comments Spindle cell melanoma![]() Additionally, a greater than 0% tumor viability correlated with worse distant metastasis outcomes based on univariate (HR, 3.72 95% CI, 1.15-12.09 P =. Additionally, there was near perfect agreement between local and central review of R status (κ statistic, 0.83 95% CI, 0.71-0.96).Ī greater than 0% tumor viability correlated with worse distant DDFS outcomes in univariate (HR, 4.41 95% CI, 1.37-14.21 P =. Investigators noted moderate agreement in local and central review of histologic types (κ statistic, 0.51 95% CI, 0,41-0.61) as well as histologic grades (κ statistic, 0.43 95% CI, 0.31-0.56). According to the investigators, long-term data from RTOG 0630 support reduced target volumes as appropriate for image-guided radiotherapy. Additionally, 81.5%, 15.6%, and 1.5% of patients had R0, R1, and R2 resections based on local read, as well as 83.0%, 14.8%, and 0.0% by central review. Overall, 18.9% of patients had grade 1 disease, 29.4% had grade 2 disease, and 49.7% had grade 3 disease per local grading, with corresponding figures of 9.1%, 23.1%, and 59.4% per central review. Per central review, the most common histologic diagnoses included undifferentiated pleomorphic sarcoma (29.4%), liposarcoma (16.1%), myxofibrosarcoma (14.0%), and leiomyosarcoma (10.5%). Between both patient populations, the most common histologic diagnoses based on review by local pathologists included liposarcoma (26.6%), undifferentiated pleomorphic sarcoma (25.2%), undifferentiated spindle cell sarcoma (21.7%), and leiomyosarcoma (11.9%). The analysis included data from 79 patients in the RTOG 0630 trial and 64 patients in the RTOG 9514 trial. Investigators calculated OS and DFS rates using the Kaplan-Meier method. Secondary objectives included comparing local and central reads of histologic type, histologic grade, and R status. The primary objective of the analysis was correlating the percentage of tumor viability after surgery with survival and disease outcomes. In RTOG 0630, patients received preoperative radiotherapy only. In RTOG 9514, patients received chemotherapy interdigitated with radiotherapy. Investigators of the ancillary analysis used long-term data from the phase 2 RTOG 0630 trial and the phase 2 RTOG 9514 trial. “To this end, pCR should be considered a prognostic factor for clinical outcomes in future clinical trials.” ![]() “The ancillary analysis with RTOG studies 95 has demonstrated that pCR was associated with improved survival outcomes in patients with who receive preoperative therapy,” the study authors stated. 01) and DFS vs those who achieved less than a pCR (HR, 4.91 95% CI, 1.51-15.93 P =. Investigators reported that pCR was associated with better OS ( P =. The 5-year disease-free survival (DFS) rates were 88.9% (95% CI, 68.4%-100.0%) and 62.7% (95% CI, 46.6%-78.8%) for the RTOG 9514 population in those with 0% and greater than 0% tumor viability, respectively. 01) investigators could not determine the hazard ratio (HR) for tumor viability because there were no events in the 0% tumor viability group. Patients with greater than 0% tumor viability experienced significantly worse OS in univariate ( P =. In the 0% tumor viability group, the 5-year overall survival (OS) rate was 100% across both studies. Investigators reported that 123 patients were evaluable for a pCR across both respective studies, including 27.5% of those in RTOG 9514 and 19.4% in RTOG 0630.
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